《植物生理学报》 2013, 49(3): 201-216

镰孢菌属真菌次生代谢产物的研究进展

张晓伟^1,2, 张栋^1,*

1中国科学院上海生命科学研究院植物生理生态研究所植物分子遗传国家重点实验室, 上海200032; 2中国科学院大学, 北京

通信作者：张栋；E-mail: dzhang01@sibs.ac.cn；Tel: 021-54924075

摘　要：

镰孢菌属包括禾谷镰孢、串珠镰孢和尖孢镰孢等主要的植物病原真菌, 能够产生多种次生代谢产物。依据结构和合成途径, 次生代谢产物可以分为聚酮类(黄色镰刀菌素、伏马毒素和玉米赤霉烯酮等)、萜类(单端孢霉烯和类胡萝卜素等)和非核糖体多肽类(铁载体等)三种主要的类型。其中, 萜类中的单端孢霉烯和聚酮类的伏马毒素对人畜的健康威胁最大。本文对这些次生代谢产物的种类、作用、合成及其调节机制进行简单的概述。

关键词：镰孢菌属真菌; 次生代谢产物; 聚酮类; 萜类; 非核糖体多肽类

收稿：2012-12-21   修定：2013-01-22

资助：国家基础研究项目(2011CB100702)和中国科学院知识创新项目(KSCX2-EW-N-06)。

Recent Advances of Secondary Metabolites in Genus Fusarium

ZHANG Xiao-Wei^1,2, ZHANG Dong^1,*

¹National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Science, Shanghai 200032, China; ²University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: ZHANG Dong; E-mail: dzhang01@sibs.ac.cn; Tel: 021-54924075

Abstract:

The genus Fusarium includes a number of important plant pathogens such as Fusarium graminear-um, Fusarium moniliforme and Fusarium oxysporum, which are capable of producing many secondary metabo-lites. According to structure and biosynthetic pathway, the secondary metabolites can be grouped into three classes: polyketides including aurofusarin, fumonisin and zearalenone; terpenes including trichothecene and carotenoid; nonribosomal peptides including siderophore. Among these, trichothecene and fumonisin are myco-toxins that affect human, animal health. Here we review current understanding of the classification, function, biosynthesis and regulation of the secondary metabolites produced by Fusarium fungi.

Key words: Fusarium; secondary metabolites; polyketides; terpenes; nonribosomal peptides